Full resolution (JPEG) - On this page / på denna sida - VIII. Digestion - VI. Absorption
<< prev. page << föreg. sida << >> nästa sida >> next page >>
Below is the raw OCR text
from the above scanned image.
Do you see an error? Proofread the page now!
Här nedan syns maskintolkade texten från faksimilbilden ovan.
Ser du något fel? Korrekturläs sidan nu!
This page has never been proofread. / Denna sida har aldrig korrekturlästs.
534 DIGESTION.
•
Rohmann and Nagano. It is, therefore, not remarkable that disac-
eharides, as well, have been found in the urine in cases of alimentary
glycosuria. 1
The investigations of Ludwig and v. Mering and others have
explained how the sugars enter into the blood-stream, namely, that they
as well as other bodies soluble in water do not ordinarily pass over into
the chylous vessels in measurable quantities, but are chiefly taken up by
the blood in the capillaries of the villi, and in this way pass into the mass
of the blood. These investigations have been confirmed by observa-
tions of I. Munk and Rosenstein 2
on human beings.
The reason why the sugars and other soluble bodies do not pass
over into the chylous vessels in appreciable quantity is, according to
Heidenhain,3
to be found in the anatomical conditions, in the arrange-
ment of the capillaries close under the layer of epithelium. Ordinarily
these capillaries find the necessary time for the removal of the water
and the solids dissolved in it. But when a large quantity of liquid,
such as a sugar solution, is introduced into the intestine at once, this is
not possible, and in these cases a part of the dissolved bodies passes into
the chylous vessels and the thoracic duct (Ginsberg and Rohmann 4
).
The passage of sugar into the urine, when at one time large quanti-
ties of sugar are taken and the assimilation limit is exceeded, can be
best explained by the assumption that a part of the sugar escaped the
liver and passed into the large circulation, or that the liver did not have
time to retain the sugar and transform it into glycogen. According to
the observations of de Filippi5 upon dogs with Eck fistula, it seems as if
the role of the liver in these cases is too highly estimated. An animal
with Eck fistula could take an unlimited quantity of starch without
glycosuria occurring. The assimilation limit was in these cases some-
what lower, but qualitatively they behave like normal animals and with
increasing sugar supply they could also retain increasing quantities of
sugar.
The introduction of larger quantities of sugar into the intestine at
one time can readily cause a disturbance with diarrheal evacuations
of the intestine. If the carbohydrate is introduced in the form of starch,
1
For the literature in regard to the passage of various kinds of sugars into the
urine, see C. Voit. Ueber die Glykogenbildung, Zeitschr. f. Biologie, 28, and F. Voit,
footnote 1, p. 396. See also Blumenthal, Zur Lehre von der Assimilationsgrenze
der Zuckerarten, Inaug.-Dissert. 1903, Strassburg and Brasch, Zeitschr. f. Biol., 50.
2
v. Mering. Arch. f. (Anat. u). Physiol., 1877; Munk and Rosenstein, Virchow’s
Arch. 123.
3
Pfluger’s Arch., 43, Suppl.
4
Ginsberg, Pfluger’s Arch., 44; Rohmann, ibid., 41.
’•
Zeitschr. f. Biol., 4!) and 50.
<< prev. page << föreg. sida << >> nästa sida >> next page >>
