Full resolution (JPEG) - On this page / på denna sida - VIII. Digestion - VI. Absorption
<< prev. page << föreg. sida << >> nästa sida >> next page >>
Below is the raw OCR text
from the above scanned image.
Do you see an error? Proofread the page now!
Här nedan syns maskintolkade texten från faksimilbilden ovan.
Ser du något fel? Korrekturläs sidan nu!
This page has never been proofread. / Denna sida har aldrig korrekturlästs.
ABSORPTION OF BILE. 541
constituents under physiological conditions despite the fact that the
occurrence of very small traces of bile-acids in the urine is disputed.
The absorption of bile-acids by the intestine seems to be positively proved
by other observations. Tappeineh ’ introduced a solution of bile-
salts of a known concentration into an intestinal knot and after a time
investigated the contents. He found that in the jejunum and the ileum,
but not in the duodenum, an absorption of bile-acids took place, and
further that of the two bile-acids only the glycocholic acid was absorbed
in the jejunum. Further, Schiff long ago expressed the opinion that
bile undergoes an intermediate circulation, in such wise that it is
absorbed from the intestine, then carried to the liver by the blood, and
lastly eliminated from the blood by this organ. Although this view has
met with seme opposition, still its correctness seems to be established by
the researches of various investigators, and more recently by Prevost and
Binet, and specially by Stadelmann and his pupils.2
After the intro-
duction of foreign bile into the intestine of an animal, the foreign bile-
acids appear again in the secreted bile.
How does the removal of large portions of the various parts of the
intestine affect absorption? Harley 3
has been able to perform a par-
tial extirpation of the large intestine and in another instance a com-
plete extirpation. This last condition increased the feces considerably,
especially because of the large increase in the water (five-fold). Fats
and carbohydrates were absorbed just as completely as in the normal.
The absorption of the proteins, on the contrary, was reduced to only
84 per cent as compared to 93-98 per cent in normal dogs. After extir-
pation, the feces sometimes did not contain any urobilin, or only traces
thereof, while bile-pigments existed in large amounts.
Erlanger and Hewlett found that dogs from which 70-83 per
cent of the total length of the jejunum and ileum had been removed,
could be kept alive, like other animals, if only the food was not too rich
in fat. When the food contained large amounts of fat then 25 per
cent was evacuated by the feces as compared to 4-5 per cent in the
normal animal. Under these same conditions the amount of nitrogen
in the feces was increased to twice the normal amount. London and
Stassow 4
found on resection of the ileum that the eliminated diges-
tion and absorption were performed by the parts of the intestine higher
1
Wien. Sitzungsber., 77.
2
Schiff, Pfliiger’s Arch., 3; Prevost and Binet, Compt. Rend., 106; Stadelmann,
see footnote 1, p. 416.
3
Proceed. Roy. Soc, 64.
4
Erlanger and Hewlett, Amer. Journ. of Physiol. 6; London and Stassow. Zeitschr.
f.physiol. Chem. 74, 349 (1911).
<< prev. page << föreg. sida << >> nästa sida >> next page >>
