Full resolution (JPEG) - On this page / på denna sida - VIII. Digestion - IV. The Pancreas and Pancreatic Juice
<< prev. page << föreg. sida << >> nästa sida >> next page >>
Below is the raw OCR text
from the above scanned image.
Do you see an error? Proofread the page now!
Här nedan syns maskintolkade texten från faksimilbilden ovan.
Ser du något fel? Korrekturläs sidan nu!
This page has never been proofread. / Denna sida har aldrig korrekturlästs.
SECRETION OF PANCREATIC JUICE. 499
secretin, which according to Bayliss and Starling,1
is the same in all
vertebrates examined, is not destroyed by heat; it is therefore not
identical with ciitorokinase, and is not considered an enzyme. It is
formed from another substance, prosecretin, by the action of acids.
According to Delezenne and Pozerski secretin occurs as such in the
intestinal mucosa, and the acids act only by the elimination of certain
bodies having a retarding action. According to Popielski secretin
action is different from acid action; and the secretin action can also be
obtained by Witte’s peptone. He believes that the secretin is not
a specific constituent of the intestine but a body widely distributed.
(Iizelt disputes the occurrence of a specific secretin and he compares
this body to peptone. Gley has obtained a solution which had a stronger
secreting action than secretin by macerating the mucosa with proteoses.2
v. Furth and Schwarz 3
also call attention to the uncertainty of our
knowledge as to the nature of secretin. According to them secretin
is probably a mixture of bodies, among which probably the choline, found
by them in the intestinal walls, acts the role of an exciter of secretion.
A second means of causing secretion is the fat, which probably only
acts after it has been saponified. Oil-soap directly introduced into the
duodenum brings about a strong secretion of pancreatic juice (Sawitsch,
Babkin 4
), and at the same time a flow of bile, gastric juice, and the
secretion of Brunner’s glands occurs. The pancreatic juice secreted
under these circumstances has about the same amount of enzymes as
the juice secreted after partaking of food.
We know very little as to how the soaps act. Fleig 5
found that by macera-
tion of the mucosa of the upper part of the duodenum with soap solution, a sub-
stance goes into solution which he calls sapokrinin, and which when introduced
into the blood brings about a strong secretion of pancreatic juice. This sapok-
rinin, which is derived from a prosapokrinin. is not an enzyme and is not identical
with secretin. After the action of chloral hydrate an abundant secretion occurs
in the duodenum (Wertheimer and Lepage), which Falloise considers as pro-
duced by a special secretin, chloral secretin. The secretion of pancreatic juice
can also be increased by alcohol, and Fleig 6
claims to have obtained a secretin,
ethyl secretin, by macerating the intestinal mucosa with alcohol. Further investiga-
tions are necessary of all these so-called secretins.
1
Journ. of Physiol., 29.
2
Delezenne and Pozerski, Compt. rend. soc. biol., 56; Popielski, Centralbl. f.
Physiol., 19; Pfluger’s Arch. 128; Gizelt, Pfluger’s Arch. 123; Gley, Compt. Rend. 151,
345.
3
v. Furth and Schwarz, Pfluger’s Arch. 124 (literature on secretin).
4
Arch des scienc. biol. de St. Petersbourg, 11, and Zeitschr. f. physiol. Chem., 56.
6
Compt. rend. soc. biol., 55, and Journ. de Physiol, et de Pathol, gen., 1904.
6
Wertheimer and Lepage, Compt. rend. soc. biol., 52; Fleig, ibid., 55; Falloise,
Bull. Acad. Roy. Belg., 1903.
<< prev. page << föreg. sida << >> nästa sida >> next page >>
