Full resolution (JPEG) - On this page / på denna sida - V. The Blood - II. The Form-elements of the Blood - Blood-pigments
<< prev. page << föreg. sida << >> nästa sida >> next page >>
Below is the raw OCR text
from the above scanned image.
Do you see an error? Proofread the page now!
Här nedan syns maskintolkade texten från faksimilbilden ovan.
Ser du något fel? Korrekturläs sidan nu!
This page has never been proofread. / Denna sida har aldrig korrekturlästs.
278 THE BLOOD.
the formula Ce3 6Hi625Ni64FeS3Cisi. According to the more recent
determinations of Hufner and Jaquet, ox-haemoglobin contains an
average of 0.336 per cent iron, and the human haemoglobin, according
to Butterfield 1
contains 0.334 per cent iron. From the iron a molec-
ular weight of 16,669 may be calculated. Barcroft and Hill have
arrived at exactly the same value by using an entirely different method
and Hufner and Gansser 2
have attempted to learn the size of the molec-
ular weight of haemoglobin by means of osmotic pressure determinations,
and they found the following approximate results: for horse-haemoglobin
15,115 and for ox-hsemoglobin 16,321. The haemoglobin from various
kinds of blood not only shows a diverse constitution, but also a different
solubility and crystalline form, and a varying quantity of water of crys-
tallization; hence we infer that there are several kinds of haemoglobin.
Bohr is a very zealous advocate of this supposition. He has been able
to obtain haemoglobins from clog- and horse-blood, by fractional crystalliza-
tion, which had different powers of combining with oxygen and contained
different quantities of iron. Hoppe-Seyler had already prepared two
different forms of haemoglobin crystals from horse-blood, and Bohr
concludes from all these observations that the ordinary haemoglobin
consists of a mixture of different haemoglobins. In opposition to this
statement, Hufner 3
has shown that only one haemoglobin exists in ox-
blood, and that this is probably true for the blood of many other animals.
Oxyhemoglobin, which has also been called h^ematoglobulin or
HjEMatocrystallin, is a molecular combination of haemoglobin and
oxygen. For each molecule of haemoglobin 1 molecule of oxygen is
present, as shown by the investigations of Hufner as well as Hufner
and Gansser, and the amount of loosely combined oxygen which is united
to 1 gram of haemoglobin (of the ox) has been determined by Hufner 4
as 1.34 cc. (calculated at 0° C. and 760 mm. mercury).
According to Bohr, the facts are different. He differentiates between four
oxyhemoglobins, according to the quantity of oxygen which they absorb, namely
1
Hoppe-Seyler, Med. chem. Untersuch., 370; Jaquet, Zeitschr. f. physiol. Chem.,
14, 296; Kossel, ibid,. 2, 150; ZinofTsky, ibid., 10; Hufner, Beitr. z. Physiol., Festschr.
f. C. Ludwig, 1887, 74-81, Journ. f. prakt. Chem. (N. F.), 22; Otto, Zeitschr. f. physiol.
Chem., 7; Inoko, ibid., 18; Abderhalden and Medigreceanu, ibid., 59; Hufner and
Jaquet, Arch. f. (Anat. u.) Physiol., 1894; E. Butterfield, Zeitschr. f. physiol. Chem.,
02.
•-’
Barcroft and Hill, Journ. of Physiol. 30; Hufner and Gansser, Arch. f. (Anat. u.)
Physiol., 1907.
:
’
Bohr, "Sur les combinaisons de l’h6moglobine avec I’oxygene," Extrait du
Bulletin de I’Academie Royale Danoise des sciences, 1890; also Centralbl. f. Physiol.
1890, ’-’4’.). Boppe-Seyler, Zeitschr. f. physiol. Chem., 2; Hufner, Arch. f. (Anat. u.)
Physiol., L894
1
Arch. f. (Anat. u.) physiol., 1901, Suppl.
<< prev. page << föreg. sida << >> nästa sida >> next page >>
